Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8645826 | Gene | 2018 | 52 Pages |
Abstract
Computational analysis of biomolecular interaction networks is now gaining a lot of importance to understand the functions of novel genes/proteins. Gene interaction (GI) network analysis and protein-protein interaction (PPI) network analysis play a major role in predicting the functionality of interacting genes or proteins and gives an insight into the functional relationships and evolutionary conservation of interactions among the genes. An interaction network is a graphical representation of gene/protein interactome, where each gene/protein is a node, and interaction between gene/protein is an edge. In this review, we discuss the popular open source databases that serve as data repositories to search and collect protein/gene interaction data, and also tools available for the generation of interaction network, visualization and network analysis. Also, various network analysis approaches like topological approach and clustering approach to study the network properties and functional enrichment server which illustrates the functions and pathway of the genes and proteins has been discussed. Hence the distinctive attribute mentioned in this review is not only to provide an overview of tools and web servers for gene and protein-protein interaction (PPI) network analysis but also to extract useful and meaningful information from the interaction networks.
Keywords
IMExDPVHPRDPTMsIIDSTRINGDIPMCLNEMOCOGssearch tool for the retrieval of interacting genes/proteinsSpikePVMEPRProtein-protein interactionGene interactionProtein-protein interactionsGenetic interactionspost-translational modificationsTopologyCluster of Orthologous GroupsKEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and GenomesDAVIDEASEInteraction networksfunctional enrichmentGiantURLMintGene ontologydatabase for annotation, visualization and integrated discoveryHuman Protein Reference DatabaseDatabasesDatabase of Interacting ProteinsPINA
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Authors
Sravan Kumar Miryala, Anand Anbarasu, Sudha Ramaiah,