Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8645828 | Gene | 2018 | 22 Pages |
Abstract
MicroRNAs (miRNAs) are important short endogenous non-coding RNAs that have critical biological roles by acting as post-transcriptional regulators of gene expression. Chromosomal region 9q22.32 encodes the miR-23b/27b/24-1 cluster and produces miR-23b, which is a pleiotropic modulator in many developmental processes and pathological conditions. Expression of miR-23b is actively suppressed and induced in response to many different stimuli. We discuss the biological functions and transcriptional regulation of this multifaceted miRNA in different tumor types, during development, upon viral infection, as well as in various clinical disorders, immune responses, as well as cardiovascular and thyroid functions. The combined body of work suggests that miR-23b expression is modulated by a diverse array of stimuli in cells from different lineages and participates in multiple gene regulatory feedback loops. Elevation of miR-23b levels appears to instruct cells to limit their proliferative and migratory potential, while promoting the acquisition of specialized phenotypes or protection from invading viruses and parasites. In contrast, loss of miR-23b can deregulate normal tissue homeostasis by removing constraints on cell cycle progression and cell motility. Collectively, the findings on miR-23b indicate that it is a very potent post-transcriptional regulator of growth and differentiation during development, multiple cancers and other biological processes. Understanding the regulation and activity of miR-23b has significant diagnostic value in many biological disorders and may identify cellular pathways that are amenable to therapeutic intervention.
Keywords
CREBHMGA2NF-κBPI3KCDKMMPEGFHER2TNFαp53Enterovirus 71miRNAsMSCsRUNX2RASSRCTSHRac1HIF-1αAtg12MARCKSbHLHTFAMWntmiRISCmiRNA-induced silencing complexVHLTcf4CDH1TP53ZEB1EV71RIG-IRetinoic acid inducible gene ICTNNB1FZD7SMADKLF2RLRE2F1TGFβR2VSMCsCyclin DCadherin 1CCNDpri-miRNAsprecursor miRNAszinc finger E-box binding homeobox 1MAP3K1ACTA2MYH11Myf5AMOTL1CAKPAK2PITX2cETS1HMGB2paired-like homeodomain 2PRDX3transforming growth factor beta receptor 2Catenin Beta 1Cyclin Hvon Hippel-Lindau tumor suppressorKruppel like factor 2hypoxia inducible factor 1 alpha subunitDNAECsMAPKPrimary miRNAPhosphatidylinositol-4,5-bisphosphate 3-kinaseNon-coding RNATLRsVLDLRSTATAktbasic helix-loop-helixdeoxyribonucleic acidinterferonIFNinterleukinTumortumor necrosis factor alphatumor protein p53EMTneuDHAmicroRNAsMyosin heavy chainCancerserine-threonine protein kinaseMesenchymal stem cellsVascular smooth muscle cellsEndothelial cellsepidermal growth factorTranscription factor 4E2F transcription factor 1runt related transcription factor 2mitochondrial transcription factor AMyogenic Factor 5Smooth muscle α-actinNon-receptor tyrosine kinaseVascular Endothelial Growth Factor (VEGF)phosphatase and tensin homologurokinase-type plasminogen activatormatrix metalloproteinaseSignal transducer and activator of transcriptionMETneuraminidaseNischarinHaloalkane dehalogenaseHes1thyroid stimulating hormoneHuman papillomavirusHPVperoxiredoxin 3cAMP responsive element binding proteinpre-miRNAsPtenTranscriptional controlcyclin-dependent kinaseepithelial-to-mesenchymal transitionVery low density lipoprotein receptorToll-like receptors
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Authors
Wei Wang, Yuji Wang, Weijun Liu, Andre J. van Wijnen,