| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8645842 | Gene | 2018 | 16 Pages |
Abstract
In addition, the PI3K/AKT/mTOR signaling pathway and hTERT up-regulation are related with cancer stemness features and drug resistance. mTOR inhibitor and TERT inhibitor combination may construct a novel strategy in cancer stem cells and it can make a double effect on telomerase enzyme. Consequently, inhibition of PI3K/AKT/mTOR signaling pathway components and hTERT activation may prohibit CSC self-renewal and surpass CSC-mediated resistance in order to develop new cancer therapeutics.
Keywords
TPP1PI3K/AKT/mTOR signalingtelomeric repeat binding factor 1TRF1telomeric repeat binding factor 2TRF24E binding protein 1RAP1eIF4E-binding protein 1POT1TIN24EBP1TERCGBMTelomerase RNA componentmTORCSCsPI3KEGFRhTERTAkttripeptidyl peptidase 1Telomerasehuman telomerase reverse transcriptaseprotection of telomeres 1Cancer stem cellsphosphate and tensin homologphosphoinositide 3-kinasemammalian target of rapamycinPtenGlioblastoma multiformeEpidermal growth factor receptor
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Authors
Fatma Dogan, Cigir Biray Avci,