Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8646154 | Gene Reports | 2018 | 29 Pages |
Abstract
Regulation of gene expression is attributed at multiple levels as transcriptional, post-transcriptional and post-translational events. Under various modes of post-transcriptional regulation, alternative polyadenylation (APA) is one of the means to generate transcriptome diversity. In alternative polyadenylation, multiple transcripts are generated from a single gene by the use of the different polyadenylation site in the 3â²UTR and other regions. It is a highly regulated process as deregulation in this is associated with the pathogenesis of various diseases. Cancer-associated genes can avoid the miRNA mediated negative regulation by using the proximal polyadenylation signal (PAS) and shorten the length of 3â²UTR. Highly proliferative or cancer cells express the transcripts with short 3â²UTR which lacks binding sites for many miRNA and regulatory RNA binding proteins (RBPs). Shortening of the 3â²UTR associated with tumor aggressiveness and poor survival of cancer patients. Global analysis of APA is now a focused area of study in context to cancer progression. In this review, we will comprehensively discuss the alternative polyadenylation process and their implication in cancer.
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Genetics
Authors
Buddhi Prakash Jain,