Genetic polymorphism in ADRB-1 is associated with type 2 diabetes susceptibility in Iranian population

β1-Adrenegic receptor (ADRB-1) leads to increase both renin and ghrelin secretions which are considered to be two hormones associated with type 2 diabetes mellitus (T2D) and insulin resistance. So, to clarify the possible impact of ADRB-1 variant in T2D, we investigated rs1801253C/G (Arg38Gly) polymorphism in a sample of Iranian population. This case-control study was carried out in 500 unrelated Iranian subjects that used Tetra amplification refractory mutation system polymerase chain reaction (Tetra ARMS-PCR) for genotyping rs1801253C/G variant. The finding demonstrated a strong association between rs1801253C/G polymorphism and T2D in versus inherited models (GG vs. CC, OR = 2.88, CI = 1.44-5.78, p = 0.003; G vs. C OR = 1.87, CI = 1.31-2.67, p = 0.0006; CG + GG vs. CC OR = 1.64 CI = 1.06-2.500 p = 0.024; and GG vs. CC + CG OR = 2.78, CI = 1.41-5.56, p = 0.0021). Our findings suggest that ADRB-1 rs1801253C/G polymorphism was prominently associated with T2D in Iranian subjects. These remarkable results needed to evaluate in other investigations with larger sample sizes and different ethnicities to confirm.