Identification, expression, and methylation of miR-7110 and its involvement in type 1 diabetes mellitus

MicroRNAs are a novel group of universally present non-coding RNA that has been implicated in the wide-ranging biological process and are critical in the manifestation of diverse disease including diabetes mellitus (DM). Although there are so many numbers of micro RNAs involved in DM none of them effective for the suppression of Type I DM (T1DM), hence there is an urgent need for identifying exact microRNAs that may serve as a candidate biomarker for T1DM. Moreover, we know that expressed sequence tags (ESTs) are random single pass sequences reads which displays the condition/tissue-specific transcribes of an organism. In the present study, we have applied bioinformatics tools to identify hsa-mir-7110-5p from diabetes mellitus using EST resources. Our studies revealed that hsa-mi-7110 was confirmed in the T1DM specific EST sequence among the predicted miRNA secondary structure. It has been known that miRNAs are known to be an important factor involved in the initiation and progression of T1DM. Based on the above information, we also deciphered the molecular mechanism and the role of miR-7110 from T1DM patients and found that miR-7110 was a novel prognostic, diagnostic and therapeutic target for T1DM.