Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8646334 | Genomics | 2018 | 44 Pages |
Abstract
Oral Squamous Cell Carcinoma (OSCC) is a serious and one of the most common and highly aggressive malignancies. Epigenetic factors such as DNA methylation have been known to be implicated in a number of cancer etiologies. The main objective of this study was to investigate physiognomies of Promoter DNA methylation patterns associated with oral cancer epigenome with special reference to the ethnic population of Meghalaya, North East India. The present study identifies 27,205 CpG sites and 3811 regions that are differentially methylated in oral cancer when compared to matched normal. 45 genes were found to be differentially methylated within the promoter region, of which 38 were hypermethylated and 7 hypomethylated. 14 of the hypermethylated genes were found to be similar to that of the TCGA-HNSCC study some of which are TSGs and few novel genes which may serve as candidate methylation biomarkers for OSCC in this poorly characterized ethnic group.
Keywords
TSSCGIHNSCCDMPSSNPsFDROSCCDMRsEpigeneticsImaWhole-genomeKEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and GenomesDAVIDtranscription start siteOral cancerDNA methylationUTR یا untranslated regions untranslated regionfalse discovery rateGene ontologydatabase for annotation, visualization and integrated discoverySingle nucleotide polymorphismsHead and neck squamous cell carcinoma
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Authors
Shngainlang Khongsti, Frederick A. Lamare, Neizekhotuo Brian Shunyu, Sahana Ghosh, Arindam Maitra, Srimoyee Ghosh,