Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8646372 | Genomics Data | 2017 | 9 Pages |
Abstract
Human clear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney tumors. We constructed a weighted gene co-expression network to identify gene modules associated with clinical features of ccRCC (n = 97). Six hub genes (CCNB2, CDC20, CEP55, KIF20A, TOP2A and UBE2C) were identified in both co-expression and protein-protein interaction (PPI) networks, which were highly correlated with pathologic stage. The significance of expression of the hub genes in ccRCC was ranked top 4 among all cancers and correlated with poor prognosis. Functional analysis revealed that the hub genes were significantly enriched in cell cycle regulation and cell division. Gene set enrichment analysis suggested that the samples with highly expressed hub gene were correlated with cell cycle and p53 signaling pathway. Taken together, six hub genes were identified to be associated with progression and prognosis of ccRCC, and they might lead to poor prognosis by regulating p53 signaling pathway.
Keywords
SAMPPISTRINGWGCNADEGsccRCCTCGAToMGSEASearch Tool for the Retrieval of Interacting GenesHuman Protein AtlasThe cancer genome atlasSignificance Analysis of MicroarraysWeighted gene co-expression network analysisProtein-protein interactionDAVIDClear cell renal cell carcinomaDEGMeSHPAdatabase for annotation, visualization and integrated discoveryprognosisProgressionDifferentially expressed geneDifferentially expressed genesHub genes
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Authors
Lushun Yuan, Liang Chen, Kaiyu Qian, Guofeng Qian, Chin-Lee Wu, Xinghuan Wang, Yu Xiao,