Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8647535 | Multiple Sclerosis and Related Disorders | 2018 | 21 Pages |
Abstract
Deterioration of cardiac autonomic regulation during the disease course associates with disabling but not with benign RRMS. Our findings suggest that assessment of cardiac autonomic regulation should be included in the evaluation of RRMS disease course. In addition, patients with disabling RRMS might be prone to unfavorable cardiovascular outcome also due to deterioration of autonomic nervous system.
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Authors
Alma Mikkola, Aku Ojanen, Juha EK Hartikainen, Anne M. Remes, Sakari Simula,