A new Framework for Modelling the Dynamics and the Breakage of Capsules, Vesicles and Cells in Fluid Flow

This paper proposes a model based on the combination of smoothed particle hydrodynamics (SPH) and coarse-grained molecular dynamics (CGMD) for the simulation of flexible particles, such as capsules, vesicles or cells, under various flow conditions. The model can deal with both breakable and unbreakable particles. Validation against data available in the literature is included, and results concerning shear and Poiseuille flow in the presence of obstacles or sharp objects are discussed.