Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8650768 | Respiratory Physiology & Neurobiology | 2018 | 8 Pages |
Abstract
Chronic intermittent hypoxia (CIH) is one of the main features of obstructive sleep apnea (OSA), which is also commonly associated with neurocognitive impairments. The present study aimed to elucidate the beneficial effect of curcumin on CIH-induced brain injuries. Male balb/c mice (6â¯â¼â¯8 weeks) were exposed to normoxia or a pattern of CIH (8â¯h/day, cycles of 180â¯s each, hypoxia: 5% O2 for 50â¯s, reoxygenation: 21% O2 for 50â¯s) for 10 weeks, along with daily curcumin treatment (50, 100, or 200â¯mg/kg, intragastrically) or its vehicle. The results showed that CIH induced significant brain edema, as well as neuronal apoptosis and astrogliosis in the cerebral cortex, brainstem, and cerebellum regions of brain. In addition, increased astrocytic AQP4 expression and activation of p38 MAPK pathway were observed after CIH exposure. Curcumin dose-dependently mitigated the brain edema and relevant cell alterations, showing a neuroprotective effect in CIH-induced brain injury. Together, these results suggest curcumin ameliorates the CIH-induced brain injuries, including brain edema, neuronal death and astrogliosis. The beneficial role of curcumin is mediated partially by regulating AQP4 and p38 MAPK pathway.
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Authors
Bo Wang, Wenyang Li, Hongyu Jin, Xinshi Nie, Hui Shen, Erran Li, Wei Wang,