Acute bronchodilator therapy does not reduce wasted ventilation during exercise in COPD

Article ID	Journal	Published Year	Pages	File Type
8650800	Respiratory Physiology & Neurobiology	2018	29 Pages	PDF

Abstract

Bronchodilator-induced improvements in respiratory mechanics were not associated with reduced wasted ventilation - a residual contributory factor to exertional dyspnea during exercise in COPD.

Keywords

FEV1 CWR TLC pCO2 IRV FVC EILV DLCO EELV MVC PO2 PEEP Bronchodilators Chronic obstructive pulmonary disease COPD Dyspnea ventilation/perfusion Alveolar ventilation minute ventilation dead space ventilation Carbon dioxide production Oxygen uptake Alveolar volume Residual volume End-expiratory lung volume Tidal volume Heart rate inspiratory capacity forced vital capacity diffusing capacity of the lungs for carbon monoxide Total lung capacity Partial pressure of oxygen Partial pressure of carbon dioxide Positive end-expiratory pressure ventilatory equivalent for carbon dioxide exercise

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Life Sciences Biochemistry, Genetics and Molecular Biology Physiology

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Acute bronchodilator therapy does not reduce wasted ventilation during exercise in COPD

Authors

Amany F. Elbehairy, Katherine A. Webb, Pierantonio Laveneziana, Nicolle J. Domnik, J. Alberto Neder, Denis E. O'Donnell, on behalf of Canadian Respiratory Research Network (CRRN) on behalf of Canadian Respiratory Research Network (CRRN),