| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8656632 | Atherosclerosis | 2018 | 35 Pages |
Abstract
Heparanase inhibition by PG545 caused a significant reduction in lipid profile and serum oxidative stress along with attenuation of atherosclerosis, aortic wall thickness, and liver steatosis. Moreover, PG545 attenuated weight gain without reducing food intake. Collectively, these findings suggest that heparanase blockade is highly effective in slowing atherosclerosis formation and progression, and decreasing liver steatosis.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Rabia Shekh Muhammad, Niroz Abu-Saleh, Safa Kinaneh, Mohammad Agbaria, Edmond Sabo, Claudia Grajeda-Iglesias, Nina Volkova, Shadi Hamoud,