Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8657669 | Cardiovascular Pathology | 2018 | 10 Pages |
Abstract
By manipulating the diet we developed a new model of CAVD in T2DM, hyperlipidemic LDLr-/-ApoB100/100 that shows several important functional, and structural features similar to CAVD found in people with T2DM and atherosclerosis including AS, cardiac dysfunction, and inflamed and calcified thickened valve cusps. Importantly, the high AS incidence of this diabetic model may be useful for mechanistic and translational studies aimed at development of novel treatments for CAVD.
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Authors
Marta Scatena, Melissa F. Jackson, Mei Y. Speer, Elizabeth M. Leaf, Mary C. Wallingford, Cecilia M. Giachelli,