Article ID Journal Published Year Pages File Type
8660288 Heart Rhythm 2018 29 Pages PDF
Abstract
Our novel results suggest that long-term exercise in CASQ2-/- mice increases susceptibility to ventricular arrhythmias by accentuating vagal antagonism during β-adrenergic challenge, which prevents HR acceleration and exacerbates abnormal RyR2 Ca2+ leak in EX CASQ2-/- VCM.
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Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
Preview
Accentuated vagal antagonism paradoxically increases ryanodine receptor calcium leak in long-term exercised Calsequestrin2 knockout mice
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