CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates electrophysiological and structural abnormalities

Article ID	Journal	Published Year	Pages	File Type
8660324	Heart Rhythm	2018	30 Pages	PDF

Abstract

PRKAG2-mutated iPSC-CMs displayed functional and structural abnormalities, which were abolished by correcting the mutation in the patient's iPSCs using CRISPR technology.

Keywords

PRKAG2 Arrhythmia Electrophysiology clustered regularly interspaced short palindromic repeats Wolff-Parkinson-White syndrome

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

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CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates electrophysiological and structural abnormalities

Authors

Ronen MSc, Binyamin MSc, Yuval MSc, Lucy N. MSc, Agnes MSc, Irina MSc, Huanhuan PhD, Kaomei PhD, Shiraz MSc, Dov MD, Silke R. MD, Mihaela MD, PhD, Michael MD, Ofer PhD,