| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8661727 | International Journal of Cardiology | 2018 | 8 Pages |
Abstract
In diabetic left ventricular dysfunction, a complex epigenetic mechanism linking miRNAs and chromatin modifying enzymes drives persistent p66Shc transcription and ROS generation. Our results set the stage for pharmacological targeting of epigenetic networks to alleviate the clinical burden of diabetic cardiomyopathy.
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Authors
Sarah Costantino, Francesco Paneni, Katharyn Mitchell, Shafeeq A. Mohammed, Shafaat Hussain, Christos Gkolfos, Liberato Berrino, Massimo Volpe, Colin Schwarzwald, Thomas Felix Lüscher, Francesco Cosentino,