Natriuretic peptides and their receptors in failing heart - Functional changes and implications for treatment

- Heart failure leads to altered cardiac expression of natriuretic peptides on transcriptional and transcriptional level.
- Expression of NPR-A and NPR-B remains unaltered in failing hearts.
- Function of NPR-A receptor becomes attenuated in failing hearts, while NPR-B function remains unaltered.
- Cardiac expression of NPR-C changes on both transcriptional and translational level patients with heart failure.
- Expression of NPR-C in failing hearts varies depending on the etiology of HF.