Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8662356 | International Journal of Cardiology | 2018 | 10 Pages |
Abstract
We demonstrate a novel mechanism for regulation of cardiac ATP production by PEDF involving AMPKα and PPARγ. PEDF promotes proteasomal degradation of AMPK and, subsequently, reduces ATP production. The reduction of ATP production associated with the decrease of ATP expenditure completed by PEDF increase energy reserves and reduces cell energy failure, prolonging the cell activity during OGD.
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Authors
Fan Qiu, Hao Zhang, Yanliang Yuan, Zhiwei Liu, Bing Huang, Haoran Miao, Xiucheng Liu, Qixiang Zhao, Hu Zhang, Hongyan Dong, Zhongming Zhang,