Article ID Journal Published Year Pages File Type
8662465 International Journal of Cardiology 2018 7 Pages PDF
Abstract
Growing evidence suggests that adverse environmental stimuli, especially during sensitive periods in early life, may lead to cardiometabolic disease in later life. However, the underlying biological mechanisms remain a mystery. Recent studies inferred that epigenetic modifications are likely involved. We review recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus-pituitary-adrenal axis as well as the immune system.
Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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