Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8662597 | International Journal of Cardiology | 2018 | 7 Pages |
Abstract
In conclusion, in response to chronic exercise adrenaline-deficient Pnmt-KO mice show concentric LV hypertrophy and impaired response to dobutamine, suggesting an initial stage of pathological cardiac hypertrophic remodeling. These results support the need for an efficient partial conversion of noradrenaline into adrenaline for prevention of blood pressure overshoot and thus pathological cardiac hypertrophic remodeling in chronic exercise.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Priscila Mendes, Raquel Martinho, Sara Leite, Leonardo Maia-Moço, Adelino F. Leite-Moreira, André P. Lourenço, Mónica Moreira-Rodrigues,