Article ID Journal Published Year Pages File Type
8662651 International Journal of Cardiology 2018 7 Pages PDF
Abstract
HG exacerbated myocardial I/R injury through amplified inflammatory response via increased HMGB1 level. EP treatment upon reperfusion conveyed significant myocardial protection against the I/R injury under both NG and HG conditions. Common to both glycemic conditions, associated mechanisms involved attenuated increase in HMGB1 level and suppression of its down-stream pathways.
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Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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Ethyl pyruvate attenuates myocardial ischemia-reperfusion injury exacerbated by hyperglycemia via retained inhibitory effect on HMGB1
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