| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8668333 | Journal of Clinical Lipidology | 2018 | 12 Pages |
Abstract
These unexpected findings indicate that measuring the circulating levels of the various domains and PTMs of PCSK9 provides more in depth information than total PCSK9 and that the prodomain and the phosphorylated state of S688 may represent novel biomarkers to explore in cardiometabolic diseases and response to treatment. In addition, our data generated new hypotheses on the function of PCSK9 PTMs in health and disease.
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Authors
Marie-Soleil PhD, Zuhier MD, PhD, Annie BSc, Josée RT, Sylvain MSc, Denis PhD, Katherine MSc, Pierre Y. MD, Rémi MD, PhD, Nabil G. PhD, Paul M. MD, Jacques MD, Benoit PhD,