Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8668381 | Journal of Clinical Lipidology | 2018 | 59 Pages |
Abstract
Overall, statin action exhibits duality in mixed dyslipidemia, as CE transfer protein-mediated normalization of the HDL CE/TG core lags markedly behind subacute reduction in elevated levels of atherogenic ApoB-containing lipoproteins. Normalization of the HDL neutral lipid core is consistent with enhanced atheroprotective function. The HDL CE/TG ratio constitutes a metabolomic marker of perturbed HDL metabolism in insulin-resistant states, equally allowing monitoring of statin impact on HDL metabolism, structure, and function.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
M. John BSc (Hons), PhD, DSc, Alexina PhD, Paul BSc, Patrice DPharm, Philippe MD,