| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8670669 | The Journal of Thoracic and Cardiovascular Surgery | 2018 | 14 Pages |
Abstract
We suggest that tumor cell-derived matrix metalloproteinase 12 promotes tumor propagation in the lung and that in the context of pulmonary malignancies matrix metalloproteinase 12 should further be tested as a potential novel therapeutic target.
Keywords
H460MMP-12LLCHPRT1GFPOrthotopic animal modelRPMIFCSELISAEnzyme-linked immunosorbent assayLungNon–small cell lung cancerNSCLCfetal calf serumRoswell Park Memorial InstituteMatrix metalloproteinase 12Tumor microenvironmentknockouthazard ratioHypoxanthine phosphoribosyltransferase 1polymerase chain reactionPCRgreen fluorescent proteinLewis lung carcinoma
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Authors
Ezra PhD, Yaniv MSc, Michal PhD, Hanna PhD, Ofra PhD, Adi MSc, Dive PhD, Devel PhD, Gail MD, Uzi MD, Oz M. MD, David BA, Hyun-Sung MD, PhD, David J. MD, Bryan MD, Amnon PhD, Ori MD, PhD,