Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8670775 | The Journal of Thoracic and Cardiovascular Surgery | 2018 | 14 Pages |
Abstract
Exendin-4 treatment improved pulmonary artery function in flow-induced PH via its direct vasoactive properties, anti-inflammatory effects, and vascular smooth muscle cell phenotypic modulation. Mitigation of pulmonary arteriopathy further potentiated right ventricle performance and reduced overall mortality. These responses were associated with suppressed expression and activity of interleukin-1β and its downstream signaling molecules. Glucagon-like peptide analogs may possess pleiotropic therapeutic potential in flow-induced PH.
Keywords
VSMCc-GMPPAHα-SMAGLP-1EX4eNOScAMPCyclic adenosine monophosphateα-smooth muscle actinexendin-4interleukinInterleukin-1βright ventricleleft ventricleVascular smooth muscle cellendothelial nitric oxide synthasePulmonary arteryphosphorylated Pulmonary arterial hypertensioncyclic guanosine monophosphatePulmonary hypertensionglucagon-like peptide-1
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Authors
Jun-Neng MD, PhD, Chih-Hsin MD, PhD, Shih-Yuan MD, Hung-Wen MD, PhD, Chwan-Yau MD, MSc, Chien-Chi MSc, Chen-Fuh MD, PhD,