Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
867151 | Biosensors and Bioelectronics | 2013 | 5 Pages |
Polydiacetylenes are ideal sensing materials due to their ability to change color in response to external stimuli. Here we report a new colorimetric, magnetically separable biosensor using a diacetylene monomer modified with a hydrophilic lysine derivative and superparamagnetic iron oxide nanoparticles. The particles demonstrated a distinct blue to red color transition when added to ethanol and could be quickly separated from solution with a common magnet. Surface functionalization of the particles with bovine serum albumin (BSA) showed the ability to capture and detect anti-BSA antibody from antiserum with a colorimetric response, demonstrating our biosensors can serve as a platform for diagnostic applications including point-of-care testing.
► We synthesized core–shell superparamagnetic nanoparticles for biosensing application. ► Functionalized nanoparticle surface with polydiacetylenes. ► Enabled rapid detection of biomarkers in complexmedia.