Recruitment and therapeutic application of macrophages in skeletal muscles after hind limb ischemia

Many patients with peripheral arterial disease have reduced muscle size, reduced strength, and impaired walking ability, which greatly affect their quality of life. Unfortunately, effective therapeutic options for patients with advanced cardiovascular disease are limited. Therefore, we aimed to examine the efficacy of intramuscular administration of macrophages on angiogenesis as well as muscle recovery. Results from this study can be used as preclinical knowledge to guide the development of cell therapy and to enhance ischemic muscle regeneration.