In vitro particulate and in vivo drug retention study of a novel polyethylene oxide formulation for drug-coated balloons

Drug-coated balloons (DCBs) have not been indicated for use in lesions below the knee (BTK). Although it is not fully understood why DCBs have failed BTK, the latest literature has indicated that a DCB that retains drug in the tissues for an extended time while also limiting particulate formation may be beneficial BTK. The polyethylene oxide balloon developed in this study had comparable drug retention to a commercially available DCB and fewer particulates. Therefore, the polyethylene oxide balloon should be investigated further for clinical importance in a porcine model using BTK lesions.