Deficiency of γδT cells protects against abdominal aortic aneurysms by regulating phosphoinositide 3-kinase/AKT signaling

Abdominal aortic aneurysm (AAA) is now considered to be an inflammatory disease. Despite numerous advances in therapeutic strategies, the mortality rate still remains high because of the progressive expansion and sudden rupture. Increasing evidence has demonstrated an important role of inflammatory response in mouse models of AAA. It has been proved that AAA formation is accompanied by infiltration of T lymphocytes. In this study, we proved the functions of γδT cells regulating inflammation, cell proliferation, and apoptosis. Taken together, our findings suggested that the γδT cell is crucial for the development of AAA and may offer a potential therapeutic target for aortic aneurysm.