| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 867417 | Biosensors and Bioelectronics | 2012 | 4 Pages |
An amperometric biosensor was proposed for the enantioanalysis of l-lysine. The biosensor is based on the impregnation of l-lysine oxidase in diamond paste. The potential used for the determination of l-lysine was 650 mV. The biosensor exhibited a linear concentration range between 1 and 100 nmol/L with a limit of detection of 4 pmol/L. The selectivity of the biosensor is high over other amino acids, such as l-serine, l-leucine, l-aspartic acid, l-glutamic acid, histamine, glycine. The proposed biosensor can be applied for the determination of l-lysine in serum samples and pharmaceutical compounds.
► A new amperometric biosensor based on modified diamond paste was proposed for the assay of l-lysine. ► The limit of detection recorded was 4 pmol/L. ► The biosensor can be successfully used for determination of l-lysine in serum samples as well as in its pharmaceutical formulations.
