Article ID Journal Published Year Pages File Type
8674194 Molecular Metabolism 2018 14 Pages PDF
Abstract
Whereas current evidence indicates that many chromatin-modifying enzymes respond to alterations in the levels of their cofactors, cosubstrates, and inhibitors, the detailed molecular mechanisms and functional consequences of such processes are largely unresolved. A deeper investigation of mechanisms responsible for altering the total cellular concentration of particular metabolites, as well as their nuclear abundance and accessibility for chromatin-modifying enzymes, will be necessary to better understand the crosstalk between metabolism, chromatin marks, and gene expression.
Related Topics
Life Sciences Neuroscience Endocrine and Autonomic Systems
Authors
, ,