Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8674194 | Molecular Metabolism | 2018 | 14 Pages |
Abstract
Whereas current evidence indicates that many chromatin-modifying enzymes respond to alterations in the levels of their cofactors, cosubstrates, and inhibitors, the detailed molecular mechanisms and functional consequences of such processes are largely unresolved. A deeper investigation of mechanisms responsible for altering the total cellular concentration of particular metabolites, as well as their nuclear abundance and accessibility for chromatin-modifying enzymes, will be necessary to better understand the crosstalk between metabolism, chromatin marks, and gene expression.
Related Topics
Life Sciences
Neuroscience
Endocrine and Autonomic Systems
Authors
Anna Nieborak, Robert Schneider,