Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8674254 | Molecular Metabolism | 2018 | 9 Pages |
Abstract
Our study unveils that the transcription factor E2F1 contributes to mammalian glucose homeostasis by directly controlling hepatic gluconeogenesis. Together with our previous finding that E2F1 promotes hepatic steatosis, the data presented here show that E2F1 contributes to both hyperlipidemia and hyperglycemia in diabetes, suggesting that specifically targeting E2F1 in the liver could be an interesting strategy for therapies against type 2 diabetes.
Keywords
CREBPCK1PPARGC1AE2F1CDK4G6PCpKaHFDFOXO1PTTperoxisome proliferator-activated receptor gamma coactivator 1-alphacAMPCyclic adenosine monophosphatepyruvate tolerance testFatty acid oxidationDiabetesHigh fat dietCell cycle regulatorsFAOphosphoenolpyruvate carboxykinase 1Liver metabolismHyperglycemiaForkhead box protein O1cAMP response element-binding proteinprotein kinase AGluconeogenesis
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Authors
Albert Giralt, Pierre-Damien Denechaud, Isabel C. Lopez-Mejia, Brigitte Delacuisine, Emilie Blanchet, Caroline Bonner, Francois Pattou, Jean-Sébastien Annicotte, Lluis Fajas,