| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8674272 | Molecular Metabolism | 2018 | 14 Pages |
Abstract
A subset of neurons in the mediobasal hypothalamus rapidly respond to physiological changes in extracellular leucine concentration. Leucine can produce both increases and decreases in neuronal Ca2+ concentrations in a neurochemically-diverse group of neurons, including some POMC and NPY/AGRP neurons. Our data reveal that leucine can signal through novel mechanisms to rapidly affect neuronal activity.
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Authors
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L. Evans, Florian T. Merkle, Frank Reimann, Fiona M. Gribble, Clemence Blouet,