| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8674297 | Molecular Metabolism | 2018 | 31 Pages |
Abstract
BA receptor activation can reverse obesity, NAFLD, and atherosclerosis by specific activation of FXR or TGR5. Our data suggest that, compared to activation of FXR or TGR5 only, dual activation of both FXR and TGR5 is a more attractive strategy for treatment of common metabolic disorders.
Keywords
CEBPαG6PCTGR5FXRCol1α1TIMP1α-SMADIOGLP-1IL-1βPCK1BATTNFαNAFLDPPARγHFDTGFβSHPCCAAT/enhancer-binding protein αfarnesoid X receptorAtherosclerosisNon-alcoholic steatohepatitisBile acidinterleukin 1βbrown adipose tissuenon-alcoholic fatty liver diseaseTransforming growth factor βtriglyceridetumor necrosis factor αHigh fat dietsmall heterodimer partnerObesityTissue inhibitor of metalloproteinase 1not significantNash glucagon-like peptide-1diet-induced obesityglucose 6-phosphatase
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Authors
Kavita Jadhav, Yang Xu, Yanyong Xu, Yuanyuan Li, Jiesi Xu, Yingdong Zhu, Luciano Adorini, Yoon Kwang Lee, Takhar Kasumov, Liya Yin, Yanqiao Zhang,