Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

Article ID	Journal	Published Year	Pages	File Type
8674334	Molecular Metabolism	2018	12 Pages	PDF

Abstract

These data provide new evidence for targeting p53 as a strategy to treat liver disease.

Keywords

IL10 ALT GTT HFD i.p.PPARα UPR pJNK DIO MCD IL6 apoB ASM ACADM methionine-choline deficient diet ACOX AAV8 acyl-CoA oxidase 1 XBP1S ABCD1 NAFLD NFκβ ACADL FATP2 ACC TNFα GAPDH Jnk DOX SPF FAS GFP AUC BSA C/EBP-homologous protein c-Jun N-terminal kinase IL1β PacC Adenovirus AST Aspartate aminotransferase Alanine aminotransferase bovine serum albumin Apolipoprotein B Non-alcoholic steatohepatitis ER stress Endoplasmic reticulum stress acetyl-CoA carboxylase Oleic acid Free fatty acid fatty acid synthase inflammation interleukin 1beta Interleukin 10 ITT QUER non-alcoholic fatty liver disease triglyceride tumor necrosis factor alpha CHOP intraperitoneal Doxorubicin diacylglycerol High fat diet dominant negative nuclear factor kappa B Lipid metabolism Obesity area under curve Nash Unfolded protein response X-box binding protein 1 green fluorescent protein Peroxisome proliferator activated receptor alpha diet-induced obesity Quercetin

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Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

Authors

Begoña Porteiro, Marcos F. Fondevila, Xabier Buque, Maria J. Gonzalez-Rellan, Uxia Fernandez, Alfonso Mora, Daniel Beiroa, Ana Senra, Rosalia Gallego, Johan FernÃ¸, Miguel López, Guadalupe Sabio, Carlos Dieguez, Patricia Aspichueta, Rubén Nogueiras,