| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8674348 | Molecular Metabolism | 2018 | 11 Pages |
Abstract
Our studies have unveiled a fascinating interaction between elevated NAMPT activity in skeletal muscle and voluntary exercise that was manifest as a striking improvement in exercise endurance.
Keywords
Sirt1RERLFDVCO2NMNNAMPTPGC-1αSirtuin-1PARPsHFDqRT-PCRPPIMCKVO2PPAR-γNAD+NmnatMitochondrial gene expressionHigh fat feedingCarbon dioxide productionInsulin sensitivitychow dietmuscle creatine kinaseOxygen consumptionNAMRespiratory exchange rationicotinamide adenine dinucleotidenicotinamide phosphoribosyl transferasenicotinamide mononucleotideNicotinamideQuantitative reverse transcriptase polymerase chain reactionexercisePyrophosphatePeroxisome proliferator-activated receptor gamma
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Authors
Sheila R. Costford, Bram Brouwers, Meghan E. Hopf, Lauren M. Sparks, Mauro Dispagna, Ana P. Gomes, Heather H. Cornnell, Chris Petucci, Peter Phelan, Hui Xie, Fanchao Yi, Glenn A. Walter, Timothy F. Osborne, David A. Sinclair, Randall L. Mynatt,