| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8674389 | Molecular Metabolism | 2017 | 43 Pages |
Abstract
Acute or binge ethanol consumption significantly increases circulating FGF21 levels in both humans and mice. However, FGF21 does not play a role in acute ethanol clearance. In contrast, chronic ethanol consumption in the absence of FGF21 is associated with significant liver pathology alone or in combination with excess mortality, depending on the type of diet consumed with ethanol. This suggests that FGF21 protects against long term ethanol induced hepatic damage and may attenuate progression of alcoholic liver disease. Further study is required to assess the therapeutic potential of FGF21 in the treatment of alcoholic liver disease.
Keywords
MCP1NAFLDLDCAcss2SCD1FGF21Cpt1βCpt1αCYP2E1CD68UCP2TNFαSREBP1cPPARαFASALTALDAlanine aminotransferaseperoxisome proliferator-activated receptor alphaStearoyl-CoA desaturase 1fatty acid synthasealcoholic liver diseasenon-alcoholic fatty liver diseasetumor necrosis factor alphastandard error of the meanCluster of differentiation 68intraperitonealsubcutaneousfibroblast growth factor 21SEMChronic ethanol consumptionwild typemonocyte chemoattractant protein 1uncoupling protein 2sterol regulatory element-binding protein-1c
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Authors
Bhavna N. Desai, Garima Singhal, Mikiko Watanabe, Darko Stevanovic, Thomas Lundasen, ffolliott M. Fisher, Marie L. Mather, Hilde G. Vardeh, Nicholas Douris, Andrew C. Adams, Imad A. Nasser, Garret A. FitzGerald, Jeffrey S. Flier, Carsten Skarke,