Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8674528 | Nutrition, Metabolism and Cardiovascular Diseases | 2018 | 18 Pages |
Abstract
Lp-PLA2 activity was higher in definite FH than in non-definite FH patients independently of LDL-C levels and statin treatment. These results highlight the particular phenotype of FH subjects among hypercholesterolemic patients. As increased Lp-PLA2 activity suggests, FH patients exhibit higher arterial inflammation that may contribute to their high cardiovascular risk. Our results reinforce the potential beneficial role of statins pleiotropic effects and the need for proper identification and treatment of FH patients.
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Authors
A. Mattina, D. Rosenbaum, R. Bittar, D. Bonnefont-Rousselot, D. Noto, M. Averna, E. Bruckert, P. Giral,