Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
867601 | Biosensors and Bioelectronics | 2011 | 5 Pages |
Abstract
We report a biosensor based on a microcantilever that is modified by a specific peptide for highly selective detection of trimethylamine (TMA). The assay is based on binding-induced bending of the peptide functionalized microcantilevers. The sensor is selectively responsive to TMA. The amplitude of microcantilever bending at equilibrium is a function of the concentration of TMA with a dynamic range from 8 ppm to 800 ppm. The detection limit is approximately 8 ppm. There is a good intra-sensor and an acceptable inter-sensor reproducibility as evidenced by the standard deviation of 5% and 15%, respectively.
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Authors
Xin Huang, Mingfu Li, Xiaohe Xu, Hongjun Chen, Hai-Feng Ji, Shuifang Zhu,