Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
867870 | Biosensors and Bioelectronics | 2010 | 6 Pages |
Abstract
Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(N-isopropylacrylamide-co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.
Related Topics
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Authors
Mara Soares da Silva, Eva R. Vão, Márcio Temtem, Luís Mafra, Jorge Caldeira, Ana Aguiar-Ricardo, Teresa Casimiro,