Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8679358 | Thrombosis Research | 2018 | 9 Pages |
Abstract
The annexin V-thrombin conjugate induced rapid thrombosis (fibrin deposition) on irradiated endothelial cells under shear stress in the parallel-plate flow device. Unconjugated, non-targeting thrombin did not induce fibrin deposition. A synergistic interaction between radiation and conjugate dose was observed. Thrombosis was greatest at the highest combined doses of radiation (25â¯Gy) and conjugate (2.5â¯Î¼g/mL). The parallel-plate flow system provides a rapid method to pre-test pro-thrombotic vascular targeting agents. These findings validate the translation of the annexin V-thrombin conjugate to pre-clinical studies.
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Authors
S. Subramanian, S.O. Ugoya, Z. Zhao, L.S. McRobb, G.E. Grau, V. Combes, D.W. Inglis, A.J. Gauden, V.S. Lee, V. Moutrie, E.D. Santos, M.A. Stoodley,