Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8679371 | Thrombosis Research | 2018 | 28 Pages |
Abstract
MicroRNAs (miRNAs) are small endogenous RNAs that post-transcriptionally regulate gene expression. In the last few years, these molecules have been implicated in the regulation of haemostasis, and an increasing number of studies have investigated their relationship with the development of thrombosis. In this review, we discuss the latest developments regarding the role of miRNAs in the regulation of platelet function and secondary haemostasis. We also discuss the genetic and environmental factors that regulate miRNAs. Finally, we address the potential use of miRNAs as prognostic and diagnostic tools in thrombosis.
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Authors
Ana B. Arroyo, Ascensión M. de los Reyes-GarcÃa, Raúl Teruel-Montoya, Vicente Vicente, RocÃo González-Conejero, Constantino MartÃnez,