Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome

Article ID	Journal	Published Year	Pages	File Type
8679451	Thrombosis Research	2018	37 Pages	PDF

Abstract

Activation of the alternative complement pathway due to low level of FH is one of the possible thrombophilic mechanisms in PAPS.

Keywords

beta-2-glycoprotein I MCP MASP β2GPI APL TMA HRP CRF CTD aHUS APs PAPs Antiphospholipid antibodies enzyme-linked immunosorbent assays connective tissue diseases Thrombophilia ELISA Primary antiphospholipid syndrome Atypical hemolytic uremic syndrome Antiphospholipid syndrome Factor H Systemic lupus erythematosus SLE Complement alternative pathway thrombotic microangiopathy membrane cofactor protein optical density

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

Preview

Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome

Authors

Hiroyuki Nakamura, Kenji Oku, Yusuke Ogata, Kazumasa Ohmura, Yoko Yoshida, Etsuko Kitano, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Yoshihiro Fujimura, Tsukasa Seya, Tatsuya Atsumi,