Calibrated automated thrombogram values in infants with cardiac surgery before and after cardiopulmonary bypass

Thrombin generation is significantly impaired in children affected by congenital heart disease, compared to healthy children and adults. CAT parameters resulted age-dependent, and thrombin generation is lower in infants aged < 6 months. After cardiac surgery with CPB, a coaugulopathy, revealed by CAT, TEG, but not by PT and aPTT assays, is persistent 12 h after surgery despite transfusions of blood products.