Plasma let-7i and miR-15a expression are associated with the effect of recombinant tissue plasminogen activator treatment in acute ischemic stroke patients

The circulating miRNAs let-7i and miR-15a showed differential expression between AIS patients receiving thrombolysis treatment (rt-PA group) and those not receiving it (non-rt-PA group). Compared to the non-rt-PA group, the rt-PA group showed upregulation of let-7i and downregulation of miR-15a.