Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8680374 | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | 2017 | 10 Pages |
Abstract
Regions with high-average SUVR are not necessarily those with the greatest tau pathology. Standardization is therefore recommended. Standardization of the data “realigns” the data such that the regional tau z-scores are informative of the disease process, that is, regions with high z-scores now coincide with regions correlated with amyloid deposition. Medial temporal structures, specifically entorhinal cortex-tau, may be useful as an AD-specific tau-PET signature due to its sensitivity to amyloid.
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Authors
Prashanthi Vemuri, Val J. Lowe, David S. Knopman, Matthew L. Senjem, Bradley J. Kemp, Christopher G. Schwarz, Scott A. Przybelski, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jr.,