Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8680456 | Alzheimer's & Dementia: Translational Research & Clinical Interventions | 2018 | 14 Pages |
Abstract
Using human studies, we propose a novel role for PLD1-dependent signaling as a critical mechanism underlying oligomer-driven synaptic dysfunction and consequent memory disruption in AD. We, further, provide the first set of preclinical studies toward future therapeutics targeting PLD1 in slowing down/stopping the progression of AD-related memory deficits as a complementary approach to immunoscavenging clinical trials that are currently in progress.
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Authors
Balaji Krishnan, Rakez Kayed, Giulio Taglialatela,