Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8681574 | Brain Stimulation | 2017 | 35 Pages |
Abstract
Our study demonstrates that the neuromodulatory effects of non-invasive focused ultrasound can be assessed in real time in awake behaving monkeys by recording discharge activity from a brain region reciprocally connected with the stimulated region. The study opens the door for further parametric studies for fine-tuning the ultrasonic parameters. The ultrasonic effect could indeed be quantified based on the direct measurement of the intensity of the modulation induced on a single neuron in a freely performing animal. The technique should be readily reproducible in other primate laboratories studying brain function, both for exploratory and therapeutic purposes and to facilitate the development of future clinical TUS devices.
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Authors
Nicolas Wattiez, Charlotte Constans, Thomas Deffieux, Pierre M. Daye, Mickael Tanter, Jean-François Aubry, Pierre Pouget,