Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8683845 | Epilepsy & Behavior | 2018 | 8 Pages |
Abstract
d-Leucine treatment was ineffective against chronic seizures after kainic acid-induced status epilepticus, but there was some efficacy during the dark cycle. Because d-leucine is highly concentrated in the pineal gland, these data suggest that d-leucine may be useful as a tool for studying circadian patterns in epilepsy. Deletion of the Tas1R2/R3 receptor protected against seizures in the MES-T test and, therefore, may be a novel target for treating seizures.
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Authors
Kylie Holden, Adam L. Hartman,